The UV Upper Air Systems units include UV-C ultraviolet germicidal devices with unidirectional flow. The UV Upper Air System is used for creating UV germ protection barriers to be placed above the doors or ceilings of the premises with contamination control or even for the treatment of air upper layers in the environment and in closed premises. The use of UV Upper Air Systems allow an intensive air disinfection, essential in all health and pharmaceutical environments, where it is necessary to operate in optimal microbiological conditions. In the health sector, it is recommended to create a decontamination area between two different areas, especially if one of them is to be kept under strict microbiological control. The mold spores and bacteria, freely circulating among spaces, are destroyed by the UV-C rays; this avoids the possibility that they settle on the surfaces.  Traditional cleaning methods are, often, not sufficient to ensure high levels of hygiene, which can be achieved only by the use of UV-C technology. With a UV Upper Air Systems, it is possible to create a bactericidal barrier between “grey” and “white” areas in a simple, immediate and secure manner, or treat the air in general, without developing heat, without chemicals and without any contraindications. It is shown that the control and an increased of hygiene level allows a consequent and general increase in quality both in the health and pharmaceutical sector, in microbiological laboratories, etc. UV Upper Air Systems achieve the elimination (99%) of bacteria such as Bacillus, Coli, Clostridium, Legionella, Vibrio, Salmonella, Pseudomonas, Staphylococcus, etc. in just a few minutes of operation.